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Fatostatin A
CAS No. 125256-00-0
Fatostatin A ( 125B11 )
产品货号. M23422 CAS No. 125256-00-0
Fatostatin 是 SREBP 激活的特异性抑制剂，它会损害 SREBP-1 和 SREBP-2 的激活。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥348 | 有现货 |
|
| 10MG | ￥543 | 有现货 |
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| 25MG | ￥980 | 有现货 |
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| 50MG | ￥1636 | 有现货 |
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| 100MG | ￥2778 | 有现货 |
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| 200MG | ￥4180 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Fatostatin A
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Fatostatin 是 SREBP 激活的特异性抑制剂，它会损害 SREBP-1 和 SREBP-2 的激活。
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产品描述Fatostatin is a specific inhibitor of?SREBP activation, it impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs.
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体外实验Cell Proliferation Assay Cell Line:DU-145 cells Concentration:0.1, 1 μM Incubation Time:3 days Result:Impaired the IGF1-induced growth at an IC50 of 0.1 μM.
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体内实验Animal Model:Four-to-five-week-old homozygous male obese (ob/ob) mice (C57BL/6J)Dosage:30 mg/kg; 150 μL Administration:i.p. injection; daily for 28 days Result:Blocked increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake.
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同义词125B11
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通路Metabolic Enzyme/Protease
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靶点Lipid
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受体SREBP
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研究领域——
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适应症——
化学信息
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CAS Number125256-00-0
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分子量294.41
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分子式C18H18N2S
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纯度>98% (HPLC)
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溶解度DMSO: 70 mg/mL (237.76 mM) Ethanol: 70 mg/mL (237.76 mM) Water: Insoluble
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SMILESCCCC1=NC=CC(C2=NC(C3=CC=C(C)C=C3)=CS2)=C1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Kamisuki S , Qian M , Abu-Elheiga L , et al. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.[J]. CHEMISTRY AND BIOLOGY -LONDON-, 2009.
